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It should be used cautiously or avoided in people with: Coronary artery disease Peripheral vascular disease (including ischemic bowel disease) History of heart attack or angina Wolff-Parkinson-White syndrome Uncontrolled high blood pressure (hypertension) Ibuprofen can also raise blood pressure in some people, particularly with frequent use or higher doses

Its a molecule that has a plasma half-life under thirty minutes that nonetheless fixes whatever ails you, in whichever direction you happen to need it fixed, with no side effects whatsoever