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These changes persisted or were only partially reversible except for the changes caused by empagliflozin and sotagliflozin which showed full reversibility upon discontinuation
Methods Data sources We used data from the UK Clinical Practice Research Datalink (CPRD) GOLD and Aurum, which was linked to the Hospital Episode Statistics Admitted Patient Care (HES APC) and Office for National Statistics (ONS) Death Registration databases
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95% CI 0.46, 0.86)though statistical significance was not reached for the latter following adjustment for multiple comparisons.57 Then, an independent group conducted an emulated target trial (ETT) over a 3-year follow-up on the same database in 1+ million patients with T2DM and found that semaglutide was associated with reduced risk of AD diagnosis specifically when compared with insulin (HR 0.33
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