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The Key Takeaways: Most common: Nausea (43%), manageable with dietary changes and timing Unique: Dysesthesia (20.9%), mild tingling sensations, not seen with Wegovy/Mounjaro Timeline: Worst during dose escalation (weeks 116), significant improvement after Discontinuation: 18.2% in TRIUMPH-4, 11.3% in TRIUMPH-1 the general obesity population tolerates it better than the osteoarthritis cohort Reversible: Stopping medication reverses side effects For most people with obesity especially severe obesity the 28.328.7% weight loss and associated health benefits outweigh the temporary discomfort during the first few months

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Because of this, ongoing constipation might be accepted as just part of the process, while stomach pain turns into something people just tolerate instead of talking about

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High FODMAP foods such as onion, garlic, wheat, and certain fruits and vegetables ferment in the gut, potentially intensifying these symptoms