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Carnitine deficiency is also observed in critical conditions that involve increased catabolism, such as trauma, sepsis and organ failure, which result in increased need for exogenous carnitine
The investigators concluded that administration of exogenous GSH had a beneficial effect on renal function by virtue of its antioxidant properties, and possibly by a vasodilator action to increase the glomerular filtration rate as well
The different mutations in SLC22A5 probably give rise to differences in severity/onset of the disease
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Thus, lipid-driven eryptosis is mainly attributed to ceramide generation in the plasma membrane (Fig
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