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At the same concentration of 580 M, Cu(OAc) 2 induced a higher upregulation of IL1A than CuCl 2 , while CuCl 2 induced a higher upregulation of IL8, HSPA1A and FOSL1 than Cu(OAc) 2

The pharmacokinetics are clear: tesofensine reaches maximum plasma concentration (Tmax) 34 hours after oral administration regardless of time of day, but the compound's extraordinarily long half-life means this initial peak is less clinically relevant than the cumulative plasma buildup over the first two weeks