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Continuous MT-1 administration beyond 3 weeks causes melanocortin receptor desensitization, where melanocytes downregulate MC1R surface expression in response to sustained agonist binding

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For an individual with a BMI over 30 who is already managing heart disease, the weight loss achieved through a personalized program can significantly reduce the strain on the cardiovascular system

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45,46 This result was confirmed by the recent pooled analysis of the STEP HFpEF and STEP HFpEF DM trials, which included 1,145 patients