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These effects were accompanied by increased NRF2-mediated transcription of brain-derived neurotrophic factor (BDNF) and decreased levels of methyl-CpG binding protein 2 (MECP2), a negative regulator of BDNF production (Tang et al., 2022)

though the first use of the ligand for a brain-targeting prodrug of methotrexate was reported in 1991 [22]

10.1016/j.apsb.2025.07.024 93 LuJ.ZhangH.CaiD.ZengC.LaiP.ShaoY.et al (2018)

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