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If you move from 0.5% to 1% to 2% in quick succession, you can't know which concentration was responsible for any observed improvements
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This minimizes any risk of cross-contamination.
Moreover, GLP-1RA reduced the risk of MACE by 14% in the overall diabetic population, with an apparent greater effect in patients with established CV disease (16% vs 6% reduction, respectively), although the lack of significant interaction between subgroups does not allow to separate them [12]
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