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Short-Term Effects (First 12 Weeks) Injection-site redness, itching, or mild swelling Headache or light nausea Temporary fatigue or drowsiness Mild water retention or bloating These symptoms often improve as your body adapts to the peptide
Alcohol increases hypoglycemia risk, especially if semaglutide suppresses appetite and reduces food intake
Mean systolic blood pressure did not change systematically in healthy subjects, but decreased 13 mmHg (from 142 mmHg at baseline) with oral semaglutide 40 mg versus placebo in subjects with T2D
Common side effects may include nausea, diarrhea, or mild stomach upset, particularly during the initial weeks of treatment
The first step is honesty about the lifestyle layer without judgement and a check on adherence