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Aardvark Therapeutics Sector: Oral gut-restricted bitter taste receptor agonists for hunger suppression HQ: San Diego, CA Year Founded: 2017 Origin Story: Aardvark Therapeutics was founded around a mechanistically distinct hypothesis: rather than suppressing appetite like GLP-1 drugs, the companys lead compound activates bitter taste receptors (TAS2Rs) confined to the gastrointestinal tract to trigger local release of satiety hormones, targeting hunger itself without systemic drug exposure
It is the single most important factor separating successful protocols from abandoned ones
Semaglutide is a GLP-1 receptor agonist, which works by mimicking a natural hormone in the body that regulates appetite and blood sugar levels
Note: While Ozempic and Wegovy are FDA-approved for diabetes and weight loss respectively, many patients access the same active ingredient through compounded semaglutide prepared by FDA-registered, inspected compounding pharmacies
patients with severe GI history sometimes prefer semaglutide
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