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People with kidney problems High doses of vitamins and minerals can put extra strain on the kidneys

The rest of the list, including Ozempic, Mounjaro, and Trulicity, is approved for type 2 diabetes, though they affect weight through the same mechanism

Note: In the US, prednisone is commonly prescribed

Conversely, liver conditions like metabolic dysfunction-associated steatotic liver disease (MASLD), also known as non-alcoholic fatty liver disease (NAFLD) can increase the risk of HF due to systemic inflammation, oxidative stress, and metabolic disturbances [34, 35]

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For example, an alginate-chitosan coacervate nanoparticle might remain intact in the acidic stomach but then swell or dissolve at the higher pH of the small intestine, thereby releasing the payload at the desired site