Increased production of melanin leads to darkening of the skin, known as hyperpigmentation
Advanced age over 60 Stomach acid production naturally declines with age
Causes of Poor Sleep: Stress, an overactive mind, hormonal imbalances, and underlying inflammation
People with liver or kidney disease , or a history of organ dysfunction
This method is reserved exclusively for the cases of severe glutathione deficiency, such as during cancer treatments, HIV/AIDS treatments, in deficiencies arising from a persons inability to efficiently produce glutathione on his/her own due to genetic mutations, or other causes
I read further information on the studies you listed on kidney storage as this seems to be where b12 is mostly found other than the liver