10.1016/j.jtumed.2019.08.003 J
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A deficiency in glutathione may lead to increased susceptibility to oxidative stress, fatigue, weakened immune function, and potential skin problems, highlighting the importance of this antioxidant in overall health
NOX activation further exacerbates oxidative stress, disrupts TJs, and directly impairs barrier integrity
It was noted that lapatinib at the dose of 100 mg/kg exhibited more evident protection against seizure phenotype than that by the dose of 50 and 100 mg/kg lapatinib had no significant effect on weight gain, indicating a good tolerance of lapatinib (Figure 1F)
Karthikeyan B, Harini L, Krishnakumar V, Kannan VR, Sundar K, Kathiresan T