Did you know these free radicals can even impact DNA and cells? Even some of the most notorious free radicals such as advanced glycation end products (AGEs), and reactive oxygen species (ROS) can be squelched by the free radical fighting antioxidant support of glutathione.
Similarly, the antitumor drug CTX induces ferroptosis in granulosa cells both in vivo and in vitro by suppressing GPX4 expression (Niu et al., 2023
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It inhibits tyrosinase, an enzyme that produces melanin
The increase of intracellular ROS is believed to correlate with the activation of nuclear factor (NF)-kappa B, a transcription activator linked to the elaboration of several cytokines (Figure 6)
the Postgraduate Research & Practice Innovation Program of Jiangsu Province (grant number KYCX17_1296)