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Discontinuation rates due to adverse events were 2.2%, 4.5% and 5.1% with retatrutide 4 mg, 9 mg and 12 mg, respectively, compared to 0.0% with placebo

Bupropion has also shown positive results, especially when used in combination with other medications

The generalizability of findings is also often limited by insufficient consideration of individual differences, such as genetic background, baseline nutritional status, gut microbiota composition, and specific OA phenotypes (e.g., metabolic vs

Bariatric surgery produces more weight loss but involves surgical risk, recovery time, and a large upfront cost

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