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To assess the ability of hepsin overexpression to protect against APAP-induced hepatotoxicity, a lethal dose of 600 mg/kg APAP was first administered to mice in each experimental group (Fig

Clapper, C

10.1016/j.molcel.2013.01.036 430 Lcking C

3 CR delays aging through epigenetic modifications Epigenetics refers to heritable changes in gene function in the absence of changes in DNA sequence

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However, vast amounts of Glutathione directly delivered in the blood through the injection can cause adverse events such as hypopigmented patches, melanoma, depletion of liver glutathione levels, and lightening of hair color