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5-Amino-1MQ was developed as a research tool to selectively block NNMT in vitro and in vivo, primarily by the Watowich group at the University of Texas at Austin
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NAD+ metabolism enzyme NNMT in cancer-associated fibroblasts drives tumor progression
That study reported changes in hormone-sensitive lipase activity, acetyl-CoA carboxylase activity, diacylglycerol release, adipocyte size, and body-weight gain in the specific models used
Animal studies report wide therapeutic windows
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