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A target-specific radiopharmaceutical selectively binds to tumor cells, enabling both diagnostic molecular imaging and therapeutic radionuclide treatment
Importantly, we established that ultrafiltered flavan-3,3,4-triol (4 ) was converted to cyanidin ( 8 ) by additional well-characterized arGSTs from maize ( Zm BZ2), arabidopsis ( A tTT19) and grapevine ( Vv GST4), and from the structure-elucidated phi-class orthologue from poplar ( Pt GSTF8), while application of GSTs unrelated to anthocyanin biosynthesis ( Vv GST2, Vv GST5, At GSTF2) did not result in cyanidin ( 8 ) formation (Fig
HIF-1 is activated due to blockade of its degradation pathway mediated by low oxygen levels, thereby increasing the expression of target genes, including those encoding glycolytic enzymes and glucose transporters, and increasing lactate secretion 67
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Triptolide downregulates the expression of NRF2 target genes by increasing cytoplasmic localization of NRF2 in A549 cells
Consistently, DMF significantly induced the expression of antioxidant proteins such as Nqo1 and Gpx4, which are critical for detoxification reaction and GSH utilization (Fig
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