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Polack G, McCray V, Tyner T, Kane S, Vu K, Yamaguchi K Jr, Merriman J, Ishimoto M, Hasson A, Sian K, Yamaguchi KT

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The chain of antioxidant protection depends on glutathione sitting at the base

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Complete protection from cell death is observed with Fer-1 and several Fer-1 analogs in rat oligodendrocytes deprived of Cys 2 , a model of the pathological process leading to periventricular leukomalacia, while more modest protection is observed in a model of Huntingtons disease and in a model of iron-induced kidney tubule damage [7]

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This may be attributed to methodological difficulties that preclude performing this kind of studies as they require longer durations of follow up

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