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GLP-1 agonists and tirzepatide may cause unpleasant side effects including dizziness, headache, indigestion or upset stomach, nausea, vomiting, diarrhoea and feeling jittery
Medicaid spending on GLP-1s hit $3.9 billion in 2023, and Medicare Part D spending on three GLP-1s hit $5.7 billion in 2022, per data from health policy research firm KFF
8 Immunotherapy (for example, anti-PD-1 therapy, sometimes in combination with anti-CTLA-4 therapy) may be offered for advanced disease and in some adjuvant settings, depending on stage and suitability
This metabolic shift promotes the breakdown of stored triglycerides and their release for energy use
Dietary guidance also plays an important role
Our experience with patients in metabolic therapy shows the biweekly 500mg schedule produces visible changes in truncal fat distribution within 68 weeks, while weekly 250mg protocols often show minimal body composition change even when total weight decreases
