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Amgen has begun recruiting for its next phase 2 trial with AMG-133, which will aim to understand AMG-133's efficacy in more patients over a longer period of time 2

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Physical symptoms extend beyond neurological manifestations to include macrocytic anemia , where Red Blood cells become enlarged and inefficient at oxygen transport

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Additionally, a randomized, double-blind, placebo-controlled trial in 2,588 healthy older adults with mild hyperhomocysteinemia found that daily supplementation with 500 g of vitamin B 12 and 400 g of folic acid for two years reduced blood homocysteine concentrations but had no benefit on depressive symptoms in those with or without depressive symptoms at baseline (110)