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In addition, the activation of GLP-1R results in a cascade that activates adenyl cyclase via G s , resulting in an increased secretion of cyclic adenosine monophosphate (cAMP) secretion and activating cAMP-dependent protein kinase (PKA)

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Ongoing research continues to explore its potential applications in nonalcoholic fatty liver disease (NAFLD), where a 2019 trial published in Lancet HIV demonstrated a 32% relative reduction in hepatic fat fraction over 12 months