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Some online vendors sell retatrutide as a research chemical or peptide for research use only. These products arent regulated by the MHRA and cant be verified for purity or correct dosing

Weight loss typically begins within 46 weeks and continues progressively with consistent medication use

This titration schedule allows the body to adapt to the medication's effects on gastric emptying and reduces the incidence of nausea and vomiting, the most commonly reported side effects

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thus, this may also be a contributing factor to the differences in observed %WL in BARI-STEP and STEP 1