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Several decisions were close, and the committee heard substantial disagreement about chemical characterization, peptide-related impurities, immunogenicity, carcinogenicity signals or uncertainty, the limited quantity and quality of human evidence, and whether existing FDA-approved therapies already address the proposed uses
In vitro models show it enhances superoxide dismutase activity for antioxidant effects and stimulates metalloproteinases for matrix turnover
However, translating elevated GH levels to measurable body composition changes in healthy individuals remains an open question
Since GHK-Cu influences processes like wound healing and collagen production, overuse or improper dosing might lead to imbalances or unintended effects