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10.2337/db17-1385 3 AkimotoH.NegishiA.OshimaS.WakiyamaH.OkitaM.HoriiN.et al (2020)

Moreover, dysbiosis alters microbial metabolites, including short-chain fatty acids (SCFAs), trimethylamine N-oxide (TMAO), and indoles, which disrupts endocrine signaling (PYY, GLP-1/2, adiponectin, and resistin), impairs insulin pathways, and promotes lipogenesis, ultimately driving obesity and diabetes (Moszak et al., 2020)

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Your body produces it naturally in every single cell, and it is most concentrated in the liver your body's detox headquarters

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