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12 These outcomes are consistent with a maintained postprandial metabolic effect but note the important confound: in these trials cagrilintide is almost always studied with semaglutide, so cleanly attributing the postprandial glucose benefit to cagrilintides gastric or glucagon effects specifically is not straightforward

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Both peptides have likewise been studied mostly in animal models, with limited human studies published to date

Histamine intolerance is thought to affect fewer than 1% of people worldwide, and although women in midlife may notice increased sensitivity, the exact prevalence remains uncertain