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Underscoring the importance that direct cholesterol engagement has in the modulation of GLP-1R function, the changes in cholesterol binding and plasma membrane behaviours introduced by the V229A substitution led to significant effects on GLP-1R trafficking and signalling in beta cells: V229A caused a decrease in GLP-1R recruitment to CCPs and receptor internalisation, accompanied by an increase in G s (measured with mini-G s ) and -arrestin 2 engagement, as well as increased plasma membrane recycling following exendin-4 stimulation
(January 2020)
The non-diabetic subpopulation includes individuals without a documented history of diabetes, as determined by diagnosis codes
I recently discussed all this and more with Tina Vilsbll, Professor at the University of Copenhagen and Research Leader at the Steno Diabetes Centre, and Michael Wagner, Senior VP, Chemistry & Drug Discovery at Dewpoint Therapeutics and Co-founder of Antaros Tracer, in a webinar called The Incretin Impact: a new era in metabolic disease and obesity drug development
Shaking introduces cavitation forces (micro-scale pressure waves) that denature peptide chainsexpect 2535% bioactivity loss even if the solution appears clear
E., & Apostolakos, J
