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Such haptenated proteins can disrupt protein folding or function and lead to direct toxicity, or can be recognized as non-self leading to immune-mediated toxicity ( FIGURE 1 Glutathione S -transferases are important enzymes that catalyze the conjugation reaction between GSH and chemically reactive drug metabolites

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Yu Q, Shuai H, Ahooghalandari P, Gylfe E, Tengholm A (2019) Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

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Habib et al., 2015