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The CCK-8 assay results showed that TGFB2 reversed the effect of Ex4 treatment on the HG-induced cell viability ( Discussion One of the key interventions for DR is controlling blood sugar levels

X-FZ critically revised the manuscript

The company claims about natural GLP-1 support represent their marketing positioning and have not been evaluated by the FDA as finished products

Furthermore, HbA1C levels in the GLP-1 RAs users were consistently higher than those in users of other second-line antihyperglycemic treatments throughout the study period, aligning with the primary analysis findings (Figure S3)

Diabetes-related thrombotic risk factors include: Hyperglycaemia-induced endothelial dysfunction , promoting a prothrombotic state Increased platelet reactivity and aggregation Elevated levels of clotting factors including fibrinogen and von Willebrand factor Chronic inflammation with raised inflammatory markers Impaired fibrinolysis , reducing the body's ability to break down clots Obesity independently increases thrombotic risk through multiple mechanisms

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