Salamah HM, Marey A, ElSayed E, Hasan MT, Mahmoud A, Abualkhair KA, Abo-Elnour DE, Abdelhaleem IA, Abd-Elgawad M (2023) Efficacy and safety of polyethylene glycol loxenatide in type 2 diabetic patients: a systematic review and meta-analysis of randomized controlled trials
In the ATTAIN-MAINTAIN trial, orforglipron's profile was "consistent with previous orforglipron Phase 3 studies." The most common adverse events were gastrointestinal-related and were generally mild-to-moderate in severity, which is expected for the GLP-1 class
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But sometimes, the tissue is so damaged that isnt enough food
Meals built around lean proteins, vegetables, fruits, whole grains, and healthy fats are generally a better fit when managing constipation on a GLP-1 medication