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In rats fed a high-fat-diet, metformin (200 mg/kg) was shown to reduce glucose absorption by inhibiting the expression of sodium glucose cotransporter-1 in the upper small intestine [36]

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ACS Appl Mater Interfaces 9:1472414740 Sonis ST (2004) The pathobiology of mucositis

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Pyridoxine (B6) is a cofactor for neurotransmitter synthesis (including GABA, dopamine, and serotonin) and for amino acid metabolism