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- At 1 month, no significant improvement in phantom limb pain was observed compared to sham treatment

This effect may be due either to inhibition of carbamyl phosphate synthase (CPS) I by -oxidation metabolites (CPS I is the first mitochondrial enzymatic step of the urea cycle) or to decreased synthesis of N -acetyl glutamic acid (NAGA) from acetyl-CoA and glutamate by NAGA synthetase (NAGA is an important cofactor of CPS I)

Patients who are about to begin or who have recently begun taking any GLP-1 medication should thus have a dilated eye examination to assess risk factors for developing NAION

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