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Methodological limitations and confounding factors Despite these promising associations, a rigorous critique of current literature reveals substantial methodological and clinical limitations that hinder translation
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A BMI of 27 or higher , along with having a weight-related issue like high blood pressure, type 2 diabetes, or elevated cholesterol
Once considered a niche category, the global AOM market is now projected to exceed $100 billion by 2030, drawing interest from biotech start-ups, major pharmaceutical firms, and investors.[130] A 2024 analysis by Goldman Sachs Research underscores the potential scale and economic impact of these therapies.[131] The report estimates that 133 million Americans could fall within the potential user base for GLP-1 medications, including 74 million for obesity treatment alone (excluding diabetes management)
doi: 10.1185/03007990802418851 111 EganAGBlindEDunderKde GraeffPAHummerBTBourcierTet al
Many of the mechanisms have been elucidated by the Jaeschke group in Kansas [18,36,37]
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