Importantly, when patients stop semaglutide, the weight they regain tends to be mostly fat mass not lean mass, leaving them potentially worse off in terms of joint support and musculoskeletal health
Who Should NOT Take GLP-1 Drugs: Eating Disorders and Mental Health Who should not take GLP-1 drugs
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Many of the cardiovascular and metabolic trials informing the discussion were not designed to evaluate ophthalmic outcomes. The authors called for prospective ophthalmology-specific studies incorporating imaging biomarkers, visual outcomes and disease-specific monitoring, noting that parsing the protective benefits or adverse effects of this rapidly growing medication class will be essential to refining disease management and improve patient outcomes. As GLP-1 therapies become increasingly common among patients with diabetes, obesity and vascular comorbiditiesprecisely the populations populating ophthalmic clinicsthe field may not have the luxury of waiting for cleaner data
Bilbrough T, Piemontese E, Seitz O
Combined with reduced appetite from GLP-1 and GIP signaling, the result is faster and larger weight loss than anything currently approved