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Importantly, when patients stop semaglutide, the weight they regain tends to be mostly fat mass not lean mass, leaving them potentially worse off in terms of joint support and musculoskeletal health

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Who Should NOT Take GLP-1 Drugs: Eating Disorders and Mental Health Who should not take GLP-1 drugs

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Many of the cardiovascular and metabolic trials informing the discussion were not designed to evaluate ophthalmic outcomes. The authors called for prospective ophthalmology-specific studies incorporating imaging biomarkers, visual outcomes and disease-specific monitoring, noting that parsing the protective benefits or adverse effects of this rapidly growing medication class will be essential to refining disease management and improve patient outcomes. As GLP-1 therapies become increasingly common among patients with diabetes, obesity and vascular comorbiditiesprecisely the populations populating ophthalmic clinicsthe field may not have the luxury of waiting for cleaner data

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Bilbrough T, Piemontese E, Seitz O

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Combined with reduced appetite from GLP-1 and GIP signaling, the result is faster and larger weight loss than anything currently approved

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