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Safety profile: No systemic toxicity was reported, and adverse effects were restricted to moderate transitory erythema in less than 5% of individuals

Research in animal models shows that Semax can upregulate brain-derived neurotrophic factor (BDNF) and its receptor TrkB in the hippocampus: BDNF Upregulation: Potently increases brain-derived neurotrophic factor expression in hippocampus and prefrontal cortex, supporting neuroplasticity and learning (PMID: 14556513) Dopamine Enhancement: Modulates dopaminergic transmission, contributing to improved focus and motivation (PMID: 14556513, PMID: 16996037) Serotonin/Norepinephrine: Influences monoamine systems involved in attention and arousal (PMID: 16362768) NGF Expression: Increases nerve growth factor, supporting neuronal survival and development (PMID: 16996037) No Classical ACTH Effects: Semax lacks the classical peripheral ACTH effects on cortisol release Selank: The Anxiolytic Stabilizer Selank is another synthetic peptide (an analog of the immune peptide tuftsin) with a markedly different mode of action

These findings prompted researchers to conclude that epithalon may help increase the quality of life for elderly patients by improving sleep quality

doi: 10.3389/fimmu.2022.837524 29 CalabreseE

Additional consequences of GLP- 1 receptor activation include appetite suppression, cardioprotective effects, and inhibition of glucagon secretion associated with inhibition of gastric emptying [6]

PMID: 116 KaurGRoyB