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14,15 Once released into the circulation, GH binds and activates the cell-surface GHR, as well as the related prolactin receptor in target tissues such as liver, muscle, bone, and adipose tissue (Fig
- (CosMos Academy)
At the anabolic level, it provides a strong impetus for muscle protein synthesis by activating the AKT/mTOR pathway and its downstream effector molecules (such as p70S6K)
When switching is not possible Patients with type 1 diabetes cannot switch from insulin to a GLP-1 medication
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