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HO-1 in cells and immature dendritic cells can delay autoimmune damage in pancreatic islet transplants and effectively maintain immune tolerance, which helps to delay the onset of T1DM in NOD mice model [19]

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doi: 10.1111/dom.12251 177 BlundellJFinlaysonGAxelsenMFlintAGibbonsCKvistTet al

[20] NAD + in the cytosol is carried into the mitochondrion by a specific membrane transport protein, since the coenzyme cannot diffuse across membranes

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