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At the time of this late fomepizole dosing, NAPQI already had depleted glutathione and formed protein adducts, complex III had begun creating superoxide, ASK1/2 had already been activated, MKK4 had been phosphorylated, and JNK activated to pJNK

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Oral procysteine increases lung glutathione and efferocytosis in smoke-exposed mice, suggesting that further studies of procysteine in COPD may be warranted