According to NICE guidance (NG145), the standard treatment is levothyroxine replacement therapy, with dose titration based on regular TSH monitoring, typically checking TSH 6-8 weeks after dose changes with the aim of achieving a TSH within the reference range
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Finally, to investigate whether semaglutide monotherapy or semaglutide in combination with BI8271, an NPY2R agonist (see electronic supplementary material [ESM] Methods: Diets and compounds), could also increase post-stroke neuronal survival, independently of metabolic effects, we determined their acute neuroprotective potential
