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Studies show most patients regain part of the lost weight and see A1C drift upward within 3-6 months

Yin W, et al

Disruptions within this axis such as leptin resistance in obesity or impaired GLP-1 signaling in diabetes are not merely consequences of these diseases but active contributors to their pathogenesis by distorting taste preferences and perpetuating pathological eating behaviors

however, at least some protection is better than none

Nan YM, Wu WJ, Fu N et al (2009) Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice

At baseline, they had an average of 4 DSM-5 alcohol use disorder symptoms (consistent with moderate severity), consumed alcohol 20/28 days and 9/28 days with heavy drinking (4+ for women and 5+ for men each day)