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b , SDS-PAGE immunoblot of electron transport chain proteins in isolated WAT mitochondria from Control and Bmal1-KO mice harvested at the indicated timepoints (n = 6)
Once ALC passes through the blood-brain barrier, it helps promote synthesization of a primary neurotransmitter in the brain known as acetylcholine, which primarily allows for communication between nerve cells
Furthermore, we found that KCNQ2-5 agonist Retigabine and AAV-mediated restoration of KCNQ5 expression level could partially reverse the defects of social ability in Gadd45a KO mice, which indicated the impaired function of K+ channels may be the major contributor to the autistic phenotype in our mouse model
