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Sleep deprivation decreases leptin (satiety hormone) and increases ghrelin (hunger hormone), making weight loss dramatically harder

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Outcomes The primary endpoint was time in the target glucose range of 3.910.0 mmol l 1 (time in range) between semaglutide (at maximum tolerated dose) and placebo, over the 28 days of AID use

Overall, 10 studies (13%) had a high risk of bias

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