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The results showed that initiation of a GLP-1 receptor agonist was associated with reduced risk of the composite outcome in participants with pre-existing disorders related to alcohol use (hazard ratio 0.72 (95% CI 0.64 to 0.81), NRD 22.49 (95% CI 29.75 to 15.23)), cocaine use (0.78 (0.67 to 0.92), NRD 40.70 (65.01 to 16.39)), and opioids use (0.70 (0.56 to 0.87), NRD 30.57 (47.96 to 13.17)), and other SUDs (0.74 (0.62 to 0.87), NRD 47.08 (70.52 to 23.63)) (fig 7 and supplementary table S14)

In addition, GLP-1 inhibits glucagon secretion in islet alpha cells, but only when blood glucose levels are higher than fasting (95, 96)