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CYP1A1 metabolism of estrogen, polyaromatic hydrocarbons, and more CYP1A2 metabolism of caffeine, duloxetine, bupropion, aflatoxin B, and more CYP2A6 metabolism of nicotine, coumarin, and more CYP2B6 metabolism of ketamine, methadone, sertraline, and more CYP2C9 metabolism of warfarin, rosuvastatin, celecoxib, and more CYP2C19 metabolism of clopidogrel, some proton pump inhibitors, more CYP2D6 metabolism of some antidepressants, antipsychotics, more CYP3A4 metabolism of half of all prescription drugs CYP2E1 metabolism of fatty acids, alcohol, and some anesthetics Phase II detoxification genes: UGT, GST, Nrf2 Phase II detoxification involves taking the metabolites of phase I and modifying them to be easily excreted through conjugation with sulfur, glutathione, glucuronic acid, amino acids, or methyl groups

When a peptide meets its receptor, its like a text message to the cell: Repair here, Make more collagen, or Turn down inflammation. Many therapeutic peptides are synthetic or lab-refined versions of molecules your body already produces, so they tend to work by amplifying or fine-tuning the bodys own signals rather than overriding them

What signaling networks integrate these pathways

doi: 10.3390/cancers11081086 116 YanTYanNWangPXiaYHaoHWangGet al

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