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50,51 Overall, SIRT1 functions as a key metabolic sensor and epigenetic regulator, with both expression and enzymatic activity finely tuned by internal and external cellular signals
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Plasmids pEGFP-RhoA (#23224) coding for RhoA protein fused to EGFP inside the pEGFP-C3 vector, mCherry2-N1 (#54517) coding for mCherry under cytomegalovirus promoter, dTomato-2xrGBD (#129625) coding for dimericTomato fused to a double rhotekin G protein-binding domain inside the pEGFP-C1 backbone, and pBABE-puro-GFP-progerin (#17663) coding for D50 lamin A fused to GFP inside the pBABE-puro vector were from Addgene
Both primary and secondary hypogonadism present with persistent low levels of testosterone, but primary hypogonadism is also associated with elevated luteinizing hormone (LH) while secondary hypogonadism may present with low or normal LH
Brain 2018;141:1917-33
2007 May;75(2):176-84
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