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Absorption rates can vary slightly depending on: Injection site Abdominal injections may be absorbed slightly faster than thigh injections Injection depth Proper subcutaneous technique ensures consistent absorption Site rotation Regular rotation prevents lipohypertrophy (fatty lumps) that can affect absorption Renal and Hepatic Function The impact of kidney and liver function varies by medication: Exenatide is contraindicated if your kidney function is severely reduced (eGFR/CrCl below 30 mL/min) Lixisenatide is not recommended in severe renal impairment (eGFR below 15 mL/min) Semaglutide, dulaglutide, and liraglutide generally don't require dose adjustment for mild to moderate kidney or liver impairment, but should be used with caution in severe impairment Drug Interactions GLP-1 medications can affect the absorption of oral medications due to delayed gastric emptying