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Contraindications Noted in Published Research Because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, the literature consistently identifies active or prior malignancy, and precancerous conditions, as contraindications for IGF-1 LR3 research use

A recent meta-analysis revealed that patients with T2DM have a 34% higher risk of developing PD compared with nondiabetic patients

Fritz IB, Arrigoni-Martelli E

doi:10.1096/fj.10-163311