More isnt always better, and high doses (such as anything over 2,000 mg) can do more harm than good if your body cant absorb them
Jpn Heart J 37(3):401407 Poteshkina NG, Krylova NS, Maslova MY, Kovalevskaya EA, Svanadze AM, Selivanova GB (2022) Hemodynamics at different levels of salt intake in patients with hypertrophic cardiomyopathy of different age groups
(Source 1) Suboptimal and deficient glutathione levels are associated with aging and an increased risk for chronic diseases, including: Mitochondrial dysfunction Neurodegenerative disease, including Alzheimers and Parkinsons disease Cancer Chronic liver disease Metabolic disease, including diabetes and hypertension Cardiovascular disease Pulmonary Infertility Autoimmune diseases, including lupus and multiple sclerosis Mental health disorders Cystic fibrosis (Source 1, 2) A viral illness, including SARS-CoV-2, the virus that causes Covid-19, can also cause glutathione deficiency
Insufficient levels of B12 can therefore reduce normal red blood cell production, which can impair oxygen delivery
Therefore, it is possible that the increased mTORC1 activation measured in FoB upon Gclc deletion can be a consequence of ROS accumulation and activation of the PI3K/AKT axis
[PMID: 30279308] PubMed record related to this compound for laboratory literature review
