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See the Endocrine Society guideline on adult growth hormone deficiency

Elevated intracellular concentration of calcium induces A aggregation in the AD brain and activates human mast cells to release inflammatory mediators (Kempuraj et al., 2005

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These findings suggest that oxidative stress has an important role in controlling the A level in neurons differentiated from DS patient-derived iPSCs and that N-acetylcysteine can be a potential therapeutic option to ameliorate the A secretion

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