NADPH plays a key role in cellular antioxidation systems by providing reducing equivalents to generate reduced forms of antioxidant molecules, which are highly corrected with cancer cell biological behaviors
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The mechanism is likely related to the metabolic changes, reduced caloric intake combined with the body adjusting to higher drug levels
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Studies have demonstrated that individuals with T2DM exhibit reduced glucose oxidation and increased reliance on lipid metabolism, which may exacerbate insulin resistance and contribute to mitochondrial dysfunction (39)
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